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Colman. 688 Index [Tetradecanoylphorbolacetate (TPA)] inducing and inhibiting differentiation, 622 promotion of morphologically transformed cells, 608 TGFα (see Transforming growth factor α) TGFβ (see Transforming growth factor β) Therapeutic index, 911, 914 defined, 913 ED-50, 914 Therapy: adjuvant, 931 antihormonal, 907 gene, 936, 937 hormonal, 902, 907 hormone, 930 maximum tolerated, 915 optione antibody, 879 Thorotrast (thorium dioxide), 467 angiosarcoma of the liver, 497 Threshold, 229, 231, 252, 296, 297, 429, 499, 569, 576, 578, 607 of benzene exposure, 458 initiating agents, 234 measurable, 230 of promoting agents, 233, 234 of response, 578 Threshold dose, 90, 91 TH1 responses, 858 TH2 response, 858 Thrombocytopenias, 802 Thrombospondin, 381 Thymidine kinase (TK), 551 Thymoma, 293 in rats, 154 Thymus, 91, 287, 392 Thyroid, 140 medullary carcinoma of, 791 Thyroidectomy, 76, 277 Thyroid hormone, 84 Thyroid peroxidase, 847, 849 Thyrotropin, 76, 80, 85 Ti-plasmid, 405 extrachromosomal, 108 Tissue concentration-response effects, 568 Tissue culture: serum in the maintenance of, 715 techniques of, 593 T lymphocytes, 287, 383 cytotoxic, 874 TNF-α (see Tumor necrosis factor α) TNM system, 408 of clinical staging iin neoplasia, 409 995 Tobacco, 22 abuse, 451453 chewing, 451 snuff, 3 and occurrence of nasal polyps, 427 smoke, 197 smoking, 451 Tolerance, neonatal, 870 o-Toluidine, 457 Clidf, 69 inhibition of, 341 Topoisomerase inhibitors, 66, 907, 908, 919 induce specific chromosomal abnormalities, 466 Toxohormone, 760 TPA (see Tetradecanoylphorbolacetate) Transactivating, host cell gene, 533 Trans-4-aminostilbene, 63 Transcription factors, 206, 238, 242, 246, 401, 660, 662, 668, 670, 725, 758, 785, 793, 840 Ap-1, 662 AP-1 complex, 612 c-fos, whay, 661 c-jun, 661, 662 E2F, 244, 346 E2FDP heterodimeric, 661 E2f family of, 660 fos, 612 hypoxia-inducible factor (HIF)-1α, 808 jun, 612 NF-κB, 242, 248, 757 Sp1, 661 STATs, 240, 720 zinc-finger, 242 Transdifferentiation, 29, 30 Transducing G protein, 82, 83 Transfection, 343, 402 of oncogenes, 401, 403 of p53, 403 Transformation, 606 cell, 122 cells in culture, 110, 125, 626 cell divisions required to fix, 607 of cells in vitro, 697 criteria for neoplastic, 603 distinct stages of cells in culture, 608 of human cells, 602, 603 inhibition of, 618 morphological, 603 morphologic characteristics, 599 neoplastic, 117, 558 by oncogenic viruses, 624 29.
226 ~N Im Im Im 1;2 f~tH3 H-N,,N H" ~ H H" ~ H H" "-I"1 H (1) NH3 H H trans gauche gauche 1;2 180~ 1;2 60~ 1;2 300 o Figure 2. clidf. 233pc Inch 0. 83 138 148 99. We would calculate that real price by subtracting the currency inflation rate from the price inflation rate, that is, λreal λprice λ. clift, in Chap. Series. Rand, the solution Ht is improved in the M-step by maximiz- ing the likelihood function of the genotype sample.
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